Vascular Implications of a Naturally Occurring Asthma Exacerbation (NCT03679299) | Clinical Trial Compass
TerminatedNot Applicable
Vascular Implications of a Naturally Occurring Asthma Exacerbation
Stopped: Poor study recruitment
Canada3 participantsStarted 2018-10-10
Plain-language summary
Although asthma is a disease of the airways, research is now showing that asthmatics are more likely to develop cardiovascular disease (CVD) compared to non-asthmatics. Vascular dysfunction is seen in people at high risk of CVD and has been linked to inflammation. During an asthma attack, levels of inflammation in the whole body increase, which could potentially explain why asthmatics are at increased risk of CVD. In the proposed study the investigators will examine if asthma attacks lead to increased risk of CVD by evaluating inflammatory levels and vascular function directly following asthma attacks, 2 days and 14 days after discharge. The investigators will compare these results to non-asthmatics. The results from this study will help us understand why asthmatics are at increased risk of CVD.
Who can participate
Age range
18 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* between the ages of 18 and 55 years old
* waist circumference less than 88 cm for women and 102 cm for men.
* Asthma participants will be recruited from the University of Alberta Emergency Department with asthma exacerbation as their primary reason for visit.
* healthy controls will be recruited from the general population according to the same criteria, but with no history of asthma.
Exclusion Criteria:
* known heart failure or unstable cardiac disease,
* lung diseases other than asthma,
* known chronic inflammatory condition other than asthma
* known metabolic disease
* current infections,
* smoking history \> 10 pack years,
* or waist circumference \>88 cm for women and \>102 cm for men
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Flow-mediated dilation
Timeframe: Emergency Department (ED), 48 hours and 14 days post ED for asthmatics, 2 time points 48 hours apart for controls.