CompletedNot Applicable

Effect of FODMAP Restriction on Persistent GI-symptoms in Coeliac Patients

Norway80 participantsStarted 2018-10-01

Plain-language summary

The first aim of the study is to investigate the prevalence of persistent gastrointestinal symptoms and compliance with gluten-free diet and the intake of FODMAP in adult celiac patients. A web-based survey wil be performed and thereafter a randomized controlled trial to test the effect of a FODMAP reduction in patients with celiac disease with irritable bowel-like symptoms.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion Criteria: * Coeliac disease * Adherent to GFD for at least 12 months * Strictly adherent to GFD * Normal coeliac disease (CD) serology and duodenal biopsy (Marsh 0-1) * Persistent GI-symptoms defined by GSRS-IBS score of 30 or more * Living less than 2 hour from study centre Exclusion Criteria: * Pregnancy or lactating women * Use of immunomodulating drugs in the last 3 months * Use of anti-inflammatory drugs in the last 3 months * Use of antacid drugs in the last 2 months * Ongoing infection (mild infection such as upper airway infection is ok) * Other chronical bowel disorder (except for IBS) * Previous tried the LFD with guidance of a dietician

What they're measuring

Change in gastrointestinal symptoms

Timeframe: 4 weeks

Trial details

NCT IDNCT03678935

SponsorOslo University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-07-28

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