CompletedNot Applicable

Multi-center Acute Severe Ulcerative Colitis Cohort Study (MASCC)

United States97 participantsStarted 2018-11-10

Plain-language summary

Ulcerative colitis (UC) is a chronic, progressive immunologically mediated disease affecting nearly 1 million Americans. Up to one third of patients with UC will require hospitalization for severe disease (termed 'acute severe colitis (ASUC)'), often within the first year after diagnosis. Investigators will develop a large multi-center cohort of patients with ASUC with homogeneously collected detailed longitudinal clinical and laboratory data.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients 18-80 years * UC or IBD-unspecified (IBDU) diagnosed according to standard criteria * Active disease defined as Simple Clinical Colitis Activity Index \> 2 (day/night bowel frequency, urgency with defecation, blood in stool, general well-being, and extracolonic features) * Admitted to the hospital * Initiating intravenous corticosteroid therapy or medical rescue therapy Exclusion Criteria: * Patients with quiescent disease * Inability to provide informed consent * Prior colitis related surgery including J-pouch or stoma * Non-IBD related hospital admission * Women who are pregnant (from the specimen substudy only) * Non - English speaking

What they're measuring

Inpatient response to medical management

Timeframe: In-hospital (approximately 1-2 weeks)

Trial details

NCT IDNCT03669822

SponsorJohns Hopkins University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-12-31

View on ClinicalTrials.gov More Ulcerative Colitis trials