1. The purpose of this study is to detect the differences of carotid atherosclerosis severity between patients with or without OSAHS(Obstructive Sleep Apnea and Hypopnea Syndrome) in a cross-sectional study in a large sample. 2. Then a longitudinal control study is conducted to observe the progress of the carotid atherosclerosis by vascular ultrasonography and the occurrence of cerebrovascular events after the intervention of the oral appliance for treating OSAHS，and finally explore the feasibility of using oral appliance to treat OSAHS in primary prevention of ischemic stroke.
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apnea hypopnea events 0 in Times
Timeframe: initial time when patients are recruited
apnea hypopnea events 1 in Times
Timeframe: one month after oral appliance treatment
apnea hypopnea events 2 in Times
Timeframe: one and a half years after oral appliance treatment
longest apnea time 0 in Seconds
Timeframe: initial time when patients are recruited
longest apnea time 1 in Seconds
Timeframe: one month after oral appliance treatment
longest apnea time 2 in Seconds
Timeframe: one and a half years after oral appliance treatment
Blood oxygen saturation less than 90% of the total monitoring time percentage 0 in percentage
Timeframe: initial time when patients are recruited
Blood oxygen saturation less than 90% of the total monitoring time percentage 1 in percentage
Timeframe: one month after oral appliance treatment
Blood oxygen saturation less than 90% of the total monitoring time percentage 2 in percentage
Timeframe: one and a half years after oral appliance treatment
lowest Oxygen Saturation 0 in percentage
Timeframe: initial time when patients are recruited
lowest Oxygen Saturation 1 in percentage
Timeframe: one month after oral appliance treatment
lowest Oxygen Saturation 2 in percentage
Timeframe: one and a half years after oral appliance treatment
atherosclerosis plaque thickness 0 in common carotid artery in milimetre
Timeframe: initial time when patients are recruited
atherosclerosis plaque thickness 1 in common carotid artery in milimetre
Timeframe: one and a half years after oral appliance treatment
atherosclerosis plaque length 0 in common carotid artery in milimetre
Timeframe: initial time when patients are recruited
atherosclerosis plaque length 1 in common carotid artery in milimetre
Timeframe: one and a half years after oral appliance treatment
atherosclerosis plaque thickness 0 in internal carotid artery in milimetre
Timeframe: initial time when patients are recruited
atherosclerosis plaque thickness 1 in internal carotid artery in milimetre
Timeframe: one and a half years after oral appliance treatment
atherosclerosis plaque thickness 0 in carotid bulb in milimetre
Timeframe: initial time when patients are recruited
atherosclerosis plaque thickness 1 in carotid bulb in milimetre
Timeframe: one and a half years after oral appliance treatment
atherosclerosis plaque length 0 in internal carotid artery in milimetre
Timeframe: initial time when patients are recruited
atherosclerosis plaque length 1 in internal carotid artery in milimetre
Timeframe: one and a half years after oral appliance treatment
atherosclerosis plaque length 0 in carotid bolb in milimetre
Timeframe: initial time when patients are recruited
atherosclerosis plaque length 1 in carotid bolb in milimetre
Timeframe: one and a half years after oral appliance treatment
breath holding index 0 in percentage/seconds
Timeframe: initial time when patients are recruited
breath holding index 0 in percentage/seconds
Timeframe: one and a half years after oral appliance treatment
End systolic velocity of common carotid artery 0 in cm/s
Timeframe: initial time when patients are recruited
End systolic velocity of common carotid artery 1 in cm/s
Timeframe: one and a half years after oral appliance treatment
End systolic velocity of internal carotid artery 0 in cm/s
Timeframe: initial time when patients are recruited
End systolic velocity of internal carotid artery 1 in cm/s
Timeframe: one and a half years after oral appliance treatment
End systolic velocity of carotid bulb 0 in cm/s
Timeframe: initial time when patients are recruited
End systolic velocity of carotid bulb 1 in cm/s
Timeframe: one and a half years after oral appliance treatment
end diastolic velocity of common carotid artery 0 in cm/s
Timeframe: initial time when patients are recruited
end diastolic velocity of common carotid artery 1 in cm/s
Timeframe: one and a half years after oral appliance treatment
end diastolic velocity of internal carotid artery 0 in cm/s
Timeframe: initial time when patients are recruited
end diastolic velocity of internal carotid artery 1 in cm/s
Timeframe: one and a half years after oral appliance treatment
end diastolic velocity of carotid bulb 0 in cm/s
Timeframe: initial time when patients are recruited
end diastolic velocity of carotid bulb 1 in cm/s
Timeframe: one and a half years after oral appliance treatment