CompletedPhase 4

Dexamethasone Blunts the Hypotensive Effect of Spinal Anesthesia in Geriatric Patients Undergoing Lower Limb Orthopedic Surgeries

Egypt110 participantsStarted 2018-03-01

Plain-language summary

Based on the data that DEX increases the TPR and may decrease the expression of serotonin the investigator conducted this study to test the hypothesis that the prophylactic intravenous infusion (IVI) of DEX can attenuate the hypotensive effect of spinal anesthesia in elderly population.

Who can participate

Age range60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 110 patients aged 60 years or older * of the American Society of Anesthesiologists (ASA) physical status I, II or III * undergoing lower limb orthopedic surgeries. * A written informed consent was obtained from all patients to participate in the study. Exclusion Criteria: * Patients with contraindication to SA (e.g.- coagulopathy, * thrombocytopenia, * allergy to local anesthetic agent) * and those on steroid or serotonin related medications (e.g. selective serotonin reuptake inhibitor) were excluded.

What they're measuring

proportions of patients with hypotension defined as a MAP at least 25% less than the basal value at any time during the first 20 min after induction of SA before start of surgical procedure.

Timeframe: The first 20 minutes after induction of SA before start of surgical procedure.

Trial details

NCT IDNCT03664037

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-08-31

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