Combined Effect of Transcranial Direct Current Stimulation (tDCS) and Physical Activity on Gait and Functional Mobility in Participants With Multiple Sclerosis

Inclusion Criteria: * Stable and continuous access to internet service at home * Adequate home facilities (enough space, access to quiet and distraction free area) * Definite MS diagnosis, subtype relapsing-remitting (RR-MS) * Disability Status Scale (EDSS) from 1 to 6.5 with clinically significant gait deviations * Clinically stable and stable on treatment with disease modifying agents at least from 6 months * Able to independently walk with or without an assisting device (i.e. cane, crutches or walking frames) for medium-long distance * Absence of other associated medical conditions that would prevent participants from performing physical activity, such as cardiorespiratory and severe osteoarticular disorders * Able to use study equipment * Able to commit 10 consecutive daily sessions of tDCS while performing physical program with baseline and follow-up visits * Able to understand the informed consent process and provide consent to participate in the study Exclusion Criteria: * Visual, auditory and motor deficits that would prevent full ability to understand study, as judged by treating neurologist or study staff * Primary psychiatric disorder that would influence ability to participate * Receiving current treatment for epilepsy * Uncontrolled headaches and migraines. In addition, if a subject has had a change in the rate or severity of head pressure, headache, or migraine in the past two weeks, they are excluded * History of head trauma (e.g., head injury, brain surgery…