The question that the investigators aim to address in this proposal is how the local lipid mediator profiles of ceramides and eicosanoids are altered in cutaneous and ocular rosacea and how antibiotics alter the lipidome. The investigators also seek to understand how the microbiome is changed in those with and without rosacea, and how the microbiome is altered in those with rosacea. Understanding how the lipidome is modulated in rosacea with antibiotic treatment will serve as the first step in targeting therapies toward directly altering the lipidome to reduce inflammation and ultimately reduce the use of antibiotics.
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Lipidome Change in Diversity
Timeframe: 1-5 weeks
Microbiome Change in Diversity
Timeframe: 1-5 weeks
Lipidome Change in Quantity
Timeframe: 1-5 weeks
Microbiome Change in Quantity
Timeframe: 1-5 weeks