T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias

Inclusion criteria

• ✓. Patient, parent, or legal guardian must have given written informed consent and/or assent according to FDA guidelines.
• ✓. Ages 5 years to 40 years, at time of consent.
• ✓. Diagnosis of Sickle Cell Disease (Hemoglobin SS, Sβ0-thalassemia) complicated by any of the following:
• ✓. A minimum donor match of 4/8 via high resolution HLA typing at HLA-A, -B, -C, -DRB1 loci in the related setting or minimum donor match of 6/8 via high resolution HLA typing at HLA-A, -B, -C, -DRB1 loci (with the DRB1 locus as a full match requirement). An unrelated donor and cord blood search must have been completed without an eligible 8/8 matched unrelated donor or 6/8 cord blood unit available. Patients who may have acceptable cord blood donor options (4/6 or better) but are limited by cell dose of a single cord will also be eligible for the proposed study.
• ✓. Adequate function of other organ systems as measured by:
• ✓. Subjects must be human immunodeficiency virus (HIV) negative by PCR.
• ✓. Negative pregnancy test for females ≥10 years old or who have reached menarche, unless surgically sterilized.
• ✓. All females of childbearing potential and sexually active males must agree to use an FDA approved method of birth control for up to 24 months after BMT or for as long as they are taking any medication that may harm a pregnancy, an unborn child or may cause a birth defect.