Transperineal Laser Ablation for Treatment of Benign Prostatic Obstruction

Inclusion Criteria: * Male * ≥ 40 years of age * Peak urinary flow rate (Qmax): ≥ 5 mL/sec to ≤ 15 mL/sec, with a minimum voided volume of ≥ 125 mL, measured with uroflowmetry or urodynamic investigation * Post-void residual (PVR): ≤ 250 mL * Prostate volume: ≥ 30 and ≤ 120 cc, measured by transrectal ultrasound * Urodynamic investigation proven bladder outlet obstruction * Signed informed consent Exclusion Criteria: * Previous invasive prostate intervention (TURP, laser, ablation, etc.) * History of prostate or bladder cancer * Indwelling Foley catheter or clean intermittent catheterization (CIC) * PSA of ≥ 3.0 ng/mL without negative biopsies * Inability or unwillingness to tolerate temporary discontinuation of anticoagulation or anti-platelet therapy * Other conditions / status * Active urinary tract infection / prostatitis * Macroscopic haematuria without a known contributing factor * Poor detrusor muscle function or other neurological disorder that would impact bladder function (eg, multiple sclerosis, Parkinson's disease, spinal cord injuries, (diabetic) polyneuropathy) * Concurrent malignancy except basal skin cancer * History of lower urinary tract surgery (eg, TURP, laser, urinary diversion, artificial urinary sphincter, penile prosthesis) * History of pelvic radiation therapy or radical pelvic surgery * History of bladder neck contracture and/or urethral strictures within the 5 years prior to the informed consent date * Bladder stones * Medical …