Disturbance of Plasma Cytokine Parameters in Clozapine-Resistant Treatment-Refractory Schizophrenia (CTRS) and Their Association With Combination Therapy

Inclusion Criteria: * The diagnosis of schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) * 18～60 years old * Clozapine resistance was defined as used at least two antipsychotics with different chemical structures with appropriate dosages for a sufficient duration, and recently have received stable dose of clozapine 400 mg or more per day for at least 6 months. * Signed an informed consent Exclusion Criteria: * Patients to be diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) for substance abused, development delayed * Suffering from serious physical disease and can not accept the treatment * Allergic to sodium valproate, amisulpride, propofol, succinylcholine or atropine * Participated in any clinical subject within 30 days * Pregnancy or lactation * Inability to sign informed consent because of capacity due due to severe mental illness, significant psychomotor agitation or slowness test completion