Hypofractionated Radiotherapy With Sequential Chemotherapy in Marginally Resectable Soft Tissue Sarcomas of Extremities or Trunk Wall

Inclusion Criteria: * Able to provide informed consent * Eastern Cooperative Oncology Group (ECOG) performance status 0 - 2 * Age ≥18 years old * Histologic diagnosis of soft tissue sarcoma * Primary or recurrent tumor localized on extremities or trunk * Grade 2 or grade 3 tumor * Marginally resectable tumor as assessed by a multidisciplinary team * Adequate renal function (serum creatinine ≤ 1.5 ULN) * Adequate liver function (total bilirubin, AST, ALT 3x \< ULN) Exclusion Criteria: * Radiation-induced sarcoma * Second active malignancy, not including localized basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, ductal or lobular carcinoma in situ of the breast; patients with a history of other malignancies are eligible if they have been continuously disease-free for \> 10 years prior to the time of registration. * History of radiation to the affected volume * Histologic diagnosis of rhabdomyosarcoma (except pleomorphic subtype), angiosarcoma, epithelioid sarcoma, clear cell sarcoma, extraskeletal chondrosarcoma, alveolar soft part sarcoma, osteogenic sarcoma, Ewing's sarcoma/PPNET, aggressive fibromatosis, dermatofibrosarcoma protuberans * Contraindications to radiotherapy, chemotherapy or surgery * Metastatic disease except primary resectable isolated lung metastases