The Effect of Paracetamol on Brain Temperature

Inclusion Criteria * 18-year or older patients * Patient hospitalized in neuro-critical care for: * Arachnoid hemorrhage * Intra parenchymatous hematoma * stroke * Acute brain Severe injury * Post-operative complication of an act of neurosurgery or programmed neuroradiology * Sedation and mechanical ventilation planned \> 2 days * Monitoring of intracranial temperature and pressure by intraparenchymal sensor (Sophysa®) * Brain temperature \> 38.5°C for more than 30 minutes Exclusion Criteria * Known hypersensitivity to paracetamol or mannitol (excipient with known effect) * Severe hepatocellular insufficiency (ASAT or ALAT \> 5N, or bilirubin \> 2N) * Pharmacological intervention (administration of corticosteroids, NSAIDs or paracetamol) or physical intervention (external cooling technique) that may influence temperature in the last 6 hours. * Pregnant or breastfeeding women * Previous participation in this study