Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease

Inclusion Criteria: * a healthy adult * clinical diagnosis of ALS * baseline FVC \>60% predicted for age, sex and height. Exclusion Criteria: * pregnant * diagnosed cardiovascular disease * a BMI \>35 kg/m2 * currently take selective serotonin reuptake inhibitors (SSRI) * history of seizures * history of hospitalization for sepsis * respiratory infection or took antibiotic medications within the past 4 weeks * use external respiratory support during any waking hours * participate in a pharmaceutical trial to treat ALS * have any other medical condition the PI or medical director identify would make it unsuitable to participate.