CompletedNot Applicable

Families-At-risk for Interstitial Lung Disease Study

United States125 participantsStarted 2018-01-15

Plain-language summary

The interstitial lung diseases (ILDs) are a family of closely related lung conditions characterized by alveolar inflammation, injury, and fibrosis not due to infection or neoplasia. While previously considered to be rare, a recent nationwide study found that idiopathic pulmonary fibrosis (IPF), a fibrotic ILD with a median survival of only 3.8 years, affects nearly 0.5% of older adults in the U.S. While pirfenidone and nintedanib slow the progression of IPF, neither reverses fibrosis nor prevents progression of the disease,and no studies to date have tested interventions that prevent the development of fibrotic ILDs.

Who can participate

Age range35 Years – 100 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: For "At Risk" participants without clinical ILD * Age 35 years or older, however subjects who are 40 years old and above will undergo HRCT and subjects age 40-65 years old will be eligible to undergo bronchoscopy * First-degree relative with one of the following clinical diagnoses: * Idiopathic Pulmonary Fibrosis * Idiopathic Non-Specific Interstitial Lung Disease (with fibrosis) * Chronic Hypersensitivity Pneumonitis (with fibrosis) * Unclassifiable Idiopathic Interstitial Pneumonia (with fibrosis) * Patients with any ILD characterized by fibrosis on CT chest scan * Ability to provide informed consent Inclusion Criteria: For "At Risk Smoker" participants without clinical ILD * At least 50 years of age * Smoked at least 1 pack a day for 30 years Exclusion Criteria: For "At-Risk" participants without clinical ILD * Known history of interstitial lung disease * History of illicit drug use within the past year. * Lower respiratory tract infection in the past 90 days. * History of chest CT scan in the past year. * Known history of heart failure or chronic kidney or liver disease. * Pregnancy or Lactation Inclusion Criteria: For "Proband" participants with clinical ILD Age 18 years or older * Has one of the following clinical diagnoses as per ATS guidelines: * Idiopathic Pulmonary Fibrosis * Idiopathic Non-Specific Interstitial Lung Disease (with fibrosis) * Chronic Hypersensitivity Pneumonitis (with fibrosis) * Unclassifiable Idiopathic Interstitial Pneu…

What they're measuring

Number of Participants With ILA (Interstitial Lung Abnormalities)

Timeframe: During imaging (up to 1 hour)

Trial details

NCT IDNCT03641742

SponsorColumbia University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-02-11

Results submitted2023-09-01