Cardiovascular autonomic neuropathy (CAN) has been shown to be an important risk factor for cardiac diseases, particularly in diabetes. CAN may be investigated by a battery of laboratory cardiovascular autonomic reflex tests(initially described by Ewing). First screening for CAN (as proposed in diabetic patients) can be performed by assessing heart rate (HR) response to deep breathing, blood pressure (BP) and HR response to a 5 minutes stand test
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Sweating autonomic test
Timeframe: baseline