Investigation of the Glaukos® Trabecular Micro-Bypass System, Model iS3, in Subjects With Refractory Glaucoma

Inclusion Criteria: * Diagnosis of refractory open-angle glaucoma (including pigmentary and pseudoexfoliative glaucoma) that is uncontrolled despite medical therapy and/or prior conventional incisional intraocular glaucoma surgeries. * Phakic or pseudophakic. * Males or females, 45 years of age or older. Exclusion Criteria: * Traumatic, uveitic, neovascular, or angle-closure; or glaucoma associated with vascular disorders. * Active corneal inflammation or edema. * Retinal disorders not associated with glaucoma.