Clinical Application of Autologous Mitochondria Transplantation for Improving Oocyte Quality. (NCT03639506) | Clinical Trial Compass
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Clinical Application of Autologous Mitochondria Transplantation for Improving Oocyte Quality.
50 participantsStarted 2018-09
Plain-language summary
Embryo quality was ranked as one of the most important predictors in determining the success of implantation, while clinically some patients may experience repeated IVF failure due to persistent poor embryo quality.Mitochondria, as the energy factory, is confirmed being a hallmark of quality and developmental potential of human oocytes, and decreased mitochondria copy number was reported to be associated with oocyte aging and dysfunctional mitochondria would be expected to influence the late stages of oocyte maturation and early embryogenesis.The objective of this study is to evaluate the effect of mitochondria transfer from bone marrow mesenchymal stem cell on the quality of oocyte.
Who can participate
Age range
20 Years – 43 Years
Sex
FEMALE
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. Complicated with adenomyosis, endometriosis confirmed by surgery, ovarian endometriosis cyst ≥2 cm by ultrasound, all kind of malignant tumors or precancerous disease.
. Untreated hydrosalpinx.
. The man has definite factors that affect the quality of the embryo, such as persistent abnormal DNA fragment rate (\>30%) and non-obstructive spermatozoa.