Contribution of Urethral Sensory Feedback in Voiding Efficiency (NCT03637582) | Clinical Trial Compass
CompletedNot Applicable
Contribution of Urethral Sensory Feedback in Voiding Efficiency
United States18 participantsStarted 2018-11-26
Plain-language summary
The purpose of this study is to evaluate how urethral anesthesia impacts voiding efficiency in healthy women. The investigator hypothesizes that anesthetizing the urethral with lidocaine gel will decrease voiding efficiency as measured by standard bladder testing (urodynamic testing).
Who can participate
Age range18 Years – 60 Years
SexFEMALE
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Inclusion Criteria:
* Females ages 18-60 years
* No health conditions as indicated in exclusion criteria
* Able to provide informed consent and agree to the risks of the study
* Willing to abstain from caffeine and alcohol for 24 hours
* Willing to avoid taking anticholinergic medications (for reasons other than incontinence; e.g., diphenhydramine) for one week prior to the procedure
Exclusion Criteria:
* Pelvic organ prolapse past the hymen
* Multiple sclerosis, myasthenia gravis, Parkinson's Disease, stroke within the past 6 months
* Interstitial cystitis / Bladder Pain Syndrome
* Recurrent (≥ 3/year) urinary tract infections
* Positive pregnancy test at the time of consent
* Positive urine dip (\>+1nitrites or \>1+LE) and urinary symptoms at the time of consent
* \>1+ blood on urinary dip
* Morbid obesity (BMI \>40)
* Taking anticholinergic medications for urinary incontinence
* \>2 replies of ≥ "sometimes" on the Lower Urinary Tract Symptoms questionnaire at the time of consent
* Alcoholism or failed CAGE questionnaire
* Abnormal baseline uroflow
* Reported pain on baseline VAS (score \>10)