Management of Cardiovascular Disease in Kidney Disease (MaCK) Study

Inclusion Criteria: * Veteran * Age 18-80 years; * Moderate to severe CKD at the time of screening, defined as one of the following: 1) Stage 3b or 4 CKD with latest eGFR of 25-59, with diabetes mellitus, OR 2) Stage 3b or 4 CKD with latest eGFR of 25 to 45 mL/min and maximum recorded albuminuria defined as urine albumin/creatinine ratio (UACR) of 30 mg/g, OR 3) Stage 3a CKD with eGFR 46-59 ml/min with urine albumin/creatinine (UACR) 100 mg/gm Exclusion Criteria: * G6PD deficiency or known hypersensitivity to 4-aminoquinoline * Conventional contraindications for non-contrast MRI examination including * Permanent pacemaker * Automatic Implantable Cardioverter Defibrillator * Significant fear of closed space * Claustrophobia that prevents patients from participating * Inability to lie down * Abnormal liver functions or diagnosis of cirrhosis * AST and ALT more than 1.5 times the normal or INR without being anti-coagulated greater than 1.4 * History of documented non-adherence to therapy * Inability to attend treatment or follow-up scheduling * Less than 6 months since initiation of 'Statins' * Prior history of any dialysis within last 12 months, or history of diagnosed AKI in the prior three months * History of acute cardiovascular event defined as: * myocardial infarction * stroke or new diagnosis of congestive heart failure or heart failure related admission in prior 3 months * History of prolonged QTc interval 450, For patients with BBB an adjusted Q…