Effects of Antimicrobials on the Altered Skin Flora in Arsenical Keratosis

Inclusion Criteria: Drinking arsenic contaminated water (\>50 microgram/ litre) for more than 6 months Patient with moderate to severe arsenical palmar keratosis Patient voluntarily agreed to participate Patient did not receive topical application of any drug for the last three months Patient who understood the instructions of applying drug and could apply drug as per as instructions - Exclusion Criteria: Patient who received any treatment of arsenicosis within last three months Patient with diagnosed skin diseases, like- atopic dermatitis and psoriasis Any diagnosed systemic diseases, inflammatory disease and infectious condition that affect the skin, for example- diabetes melitus, SLE and hepatitis \-