UnknownNot Applicable

Localization and Mismatch Negativity

France60 participantsStarted 2018-07-10

Plain-language summary

This descriptive and observational research project aims to characterize MMN as a neuronal marker of localization deficit in single-sided deafened subjects and subjects with bilateral profound deafness treated by a cochlear implant (CI). It includes several electro-physiological and psychoacoustic assessments performed on subjects with single-sided deafness and cochlear implanted subjects, with normal-hearing subjects as control: * Evaluation of the characteristics of the MMN involved in sound localization by EEG. * Evaluation of the spatial localization abilities for a sound source presented in the open field. * Assessment of performance for speech recognition in noise. These evaluations are performed in subjects with symmetrical hearing, in a natural binaural condition and a monaural condition (with a plugged ear), in subjects with single-sided deafness and in subjects with unilateral CI

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: For symmetrical hearing subjects: * Affiliation to a social security * Normal hearing, or mild to moderate symmetrical hearing loss controlled by tone audiometry performed before inclusion (in air conduction and bone conduction, frequencies 250 Hz to 4000 Hz). * Signature of the consent form For subjects with single-sided deafness: * Affiliation to a social security * Subject having a unilateral deafness controlled by pure-tone audiometry before inclusion (in air conduction and bone conduction, frequencies 250 Hz to 4000 Hz). * Signature of the consent form For subjects with Cochlear Implants: * Affiliation to a social security * Subject with symmetrical or asymmetrical profound deafness treated by unilateral cochlear implantation. * Signature of the consent form Exclusion Criteria: * History of associated neurological disorder * Taking psychotropic drugs * Persons with complicated social or medical situations

What they're measuring

Characterization of the MMN in the group of subjects with single-sided deafness and the group of CI subjects

Timeframe: Inclusion visit

Trial details

NCT IDNCT03632551

SponsorUniversity Hospital, Toulouse

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-12-10

Contact for this trial

Soumia TAOUI

0561777704 taoui.s@chu-toulouse.fr