Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

Inclusion Criteria: * Subject is a male or female 18 years of age or older. * Subject is undergoing planned resection of known or suspected GBM. * Subject has a Karnofsky Performance Status (KPS) 70% or greater. * Subject has a life expectancy of at least 6 months, in the opinion of the Investigator. * Based on the pre-operative evaluation by neurosurgeon, the subject is a candidate for ≥ 80% resection of enhancing region. * Subject must be able to undergo MRI evaluation. * Subject meets the following laboratory criteria: * White blood count ≥ 3,000/µL * Absolute neutrophil count ≥ 1,500/µL * Platelets ≥ 100,000/µL * Hemoglobin \> 10.0 g/dL (transfusion and/or ESA allowed) * Total bilirubin and alkaline phosphatase ≤ 2x institutional upper limit of normal (ULN) * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \< 3 x ULN * Blood urea nitrogen (BUN) and creatinine \< 1.5 x ULN * Females of reproductive potential must have a negative serum pregnancy test and be willing to use an acceptable method of birth control. * Males of reproductive potential must be willing to use an acceptable method of birth control to ensure effective contraception with partner. * Able to understand and willing to sign an institutional review board (IRB)-approved written informed consent document (legally authorized representative permitted). Inclusion criteria considered during surgery: * Subject has a histologically confirmed (frozen section) diagnosis of WHO Gra…