A robust knowledge of how to reduce breast density could play a key role in breast cancer prevention in premenopausal women, but viable preventative targets to reduce breast density-associated breast cancer risk are yet to be developed. The investigators propose to investigate the effect of RANKL inhibition with denosumab on breast tissue markers in high-risk premenopausal women with dense breasts. Study findings could provide robust evidence to move forward with a clinical trial targeting RANKL inhibition in premenopausal breast cancer prevention.
Age range
35 Years
Sex
FEMALE
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Effect of denosumab on breast tissue gene pathway gene expression
Timeframe: Between baseline and day 60
Effect of denosumab on pathways that may influence breast cancer development as measured by spatial transcriptomic analysis
Timeframe: Between baseline and day 60
Effect of denosumab on pathways that may influence breast cancer development as measured by metabolomic analysis
Timeframe: Between baseline and day 60