Optical CoherenCe Tomography-gUided Coronary Intervention in Patients With Complex lesIons: a Randomized Controlled Trial (OCCUPI Trial)

Inclusion criteria * Age 19-85 years * Patients with ischemic heart diseases (including stable angina, unstable angina and acute myocardial infarction) presented with typical chest pain or objective evidences of myocardial ischemia (positive invasive or non-invasive studies, electrocardiogram (ECG) consistent with ischemia, or elevated cardiac enzymes) * Complex coronary stenotic lesions (\>50% based on visual estimate) considered for coronary revascularization with DES * Definition of complex lesions (at least one): * Acute myocardial infarction * Chronic total occlusion * Long lesion: expected stent length ≥28mm based on angiographic estimation * Calcified lesion * Bifurcation (including all techniques, one- or two-stent) * Unprotected left main disease * Small vessel diseases with reference vessel diameter less than 2.5 mm * Intracoronary thrombus visible on the angiography * Stent thrombosis * In-stent restenosis * Bypass graft lesion * Patients who provide signed informed consent Exclusion criteria * Severe hepatic dysfunction (≥3 times normal reference values) * Significant renal dysfunction (Serum creatinine \>2.0 mg/dL) * Platelet count \<100,000 cells/mm3 or \>700,000 cells/mm3, a white blood cell count of \<3,000 cells/mm3, hemoglobin \<8.0 g/dL, or other known bleeding diathesis * Hemodynamically unstable during procedures or cardiogenic shock * Pregnant women or women who might be pregnant * Life expectancy; less than 1 year * Inability t…