Tissue Alterations in Aggressive and Chronic Periodontitis

Inclusion Criteria: Age range from 30 to 45, the existence of at least 20 functioning teeth, no history of smoking, systemical health, no antibiotic use within 6 months, no periodontal therapy within 6 months, no pregnancy or lactation, no drug use, in addition; For healthy individuals, the existence of oral health * For localized aggressive periodontitis, the existence of the disease at least for 5 years, the presence of both healthy and diseased sites in the same patient. * For chronic periodontitis, the existence of the disease at least for 5 years, the presence of both healthy and diseased sites in the same patient. Exclusion Criteria: * Patients younger than 30 older than 45 years old, the absence of occlusion, drug use, pregnancy/lactation, smoking, previous antibiotic use, previous periodontal therapy, the existence of any systemical disease.