CompletedNot Applicable

Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome

United States32 participantsStarted 2018-08-15

Plain-language summary

This study is focused on assessing potential health benefits of daily consumption of potatoes, specifically its resistant starch content (i.e. nondigestible carbohydrate), on blood vessel and gut health function in adults with metabolic syndrome. It is expected that the daily consumption of potatoes for two weeks, within a diet that follows the Dietary Guidelines for Americans, will improve blood vessel function in association with decreasing gut permeability ("leaky gut") that results in the absorption of bacterial toxins that reside in the intestine. Outcomes will therefore support dietary recommendations for potatoes to support vascular and gastrointestinal health.

Who can participate

Age range18 Years – 50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Fasting glucose 100-125 mg/dL * Waist circumference \>102 cm (men), \>88 cm (women) * Fasting triglyceride \>150 mg/dL * Fasting HDL cholesterol \<40 mg/dL (men), \<50 mg/dL (women) * Non-smoker * Non-dietary supplement user (\>1-mo) * Free of gastrointestinal disorders, cardiovascular disease, cancer * No recent use of antibiotics or any medications affecting glycemia, lipidemia, or blood pressure Exclusion Criteria: * Use of anti-inflammatory agents or probiotics * Vegetarian, gluten-intolerant, carbohydrate-restricted diet * Alcohol intake \>2 drinks/d * \>7 hours/week of aerobic activity * Women who are pregnant or lactating or have initiated or changed birth control in the past 3-months * Taking medications that affect blood sugar, blood pressure, blood vessel health, or inflammation * High blood pressure or any vascular diseases * HIV, hepatitis, or blood disorders such as hemophilia * Gastrointestinal disorders * Cancer (current or past history) * Anemia

What they're measuring

Endotoxin

Timeframe: Day 14

Vascular Endothelial Function

Timeframe: Day 14 Postprandial (0, 30, 60, 90, 120 minutes)

Trial details

NCT IDNCT03624569

SponsorOhio State University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-07-16

Results submitted2022-12-20