Direct Complete Versus Staged Complete Revascularization in Patients Presenting With Acute Corona… (NCT03621501) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Direct Complete Versus Staged Complete Revascularization in Patients Presenting With Acute Coronary Syndromes and Multivessel Disease
Netherlands1,525 participantsStarted 2018-06-22
Plain-language summary
To test whether immediate complete revascularization is non-inferior to staged (but within six weeks after index procedure) complete revascularization in Patients presenting with ACS, including Non-ST-elevation ACS (NSTEACS) and ST-elevation myocardial infarction (STEMI), with multivessel disease accepted for PCI
Who can participate
Age range18 Years – 85 Years
SexALL
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Inclusion Criteria:
Inclusion criteria STEMI-ACS ST-segment elevation myocardial infarction (STEMI) Both criteria must be present for eligibility
* Chest pain for more than 20 minutes with an electrocardiographic ST-segment elevation of 1 mm or greater in two or more contiguous leads, or with a new left bundle-branch block
* Admission either within 12 hours of symptom onset or between 12 and 24 hours after onset with evidence of continuing ischemia.
Inclusion criteria for NSTE-ACS Non-ST-segment elevation myocardial infarction (NSTEMI) At least two of the following must be present for eligibility
* History consistent with new, or worsening ischemia, occurring at rest or with minimal activity
* Coronary angiography with indication to PCI
* Troponin T or I or creatine kinase MB above the upper limit of normal
* Electrocardiographic changes compatible with ischemia but not diagnostic for ST-segment elevation myocardial infarction (i.e. ST depression of 1 mm or greater in two contiguous leads, T-wave inversion more than 3 mm, or any dynamic ST shifts) 0 Unstable Angina (UA)
At least two of the following must be present in the absence of cardiomyocyte necrosis (i.e. Troponin T or I and creatine kinase MB must be within normal limits):
* History consistent with new, or worsening ischemia, occurring at rest or with minimal activity
* Coronary angiography with indication to PCI
* Electrocardiographic changes compatible with ischemia but not diagnostic for ST-segment elevation m…