Active — Not RecruitingNot Applicable

Impaired Endothelial Integrity in Patients With Embolic Stroke of Undetermined Source (ESUS)

Greece215 participantsStarted 2018-01-01

Plain-language summary

The investigators will measure endothelial glycocalyx, aortic elastic properties, oxidative stress, and their association with left ventricular (LV) and left atrial (LA) function in ESUS, cardioembolic, atherosclerotic, lacunar strokes and age- and sex-adjusted healthy individuals.

Who can participate

Age range18 Years – 75 Years

SexALL

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Exclusion criteria

✕. presence of acute haemorrhagic stroke,
✕. the presence of stroke of other determined etiology,
✕. the history of previous Ischemic stroke and/or Myocardial Infarction (MI),
✕. hypercoagulable state,
✕. active malignancy
✕. severe chronic kidney disease (eGFR\<30 ml/minute). These exclusion criteria are applied to both patients and control subjects.

What they're measuring

Comparison of endothelial glycocalyx thickness between patients with embolic stroke of undetermined source (ESUS), cardioembolic, atherosclerotic, lacunar strokes and controls

Timeframe: Baseline

Trial details

NCT IDNCT03609437

SponsorUniversity of Athens

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-10-30

View on ClinicalTrials.gov More Embolic Stroke of Undetermined Source trials