Stopped: Lack of funding
One possible reason that weight gain after transplant may interfere with new kidney function is due to the enlargement of a kidney structure called the glomerulus. The researchers believe that modest caloric intake reduction (CIR) early after kidney transplantation can reduce the enlargement (hypertrophy) of the glomerulus associated with kidney transplantation and may improve long term allograft survival, by reducing glomerular hypertrophy mediated progressive glomerulosclerosis.
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Difference in the Change in Baseline and 3 Month Glomerular Volume Between the Intervention and the Control Arm
Timeframe: Post-Perfusion (Time 0 or Study Enrollment) and 3 months
Difference in the Number of Glomerular Ki67 Positive Cells Between the Intervention and the Control Arm
Timeframe: 3 months
Difference in the Number of Glomerular DAPI Positive (Nuclei) Between the Intervention and the Control Arm
Timeframe: 3 months
Difference in the Number of TLE4 Positive (Podocyte Nuclei) Between the Intervention and the Control Arm
Timeframe: 3 months
Differences in Podocyte Detachment Rate Between the Intervention and the Control Arm
Timeframe: 3 months
Difference in the Podocyte Hypertrophic Stress Between the Intervention and the Control Arm
Timeframe: 3 months