Hyperthermic Intraperitoneal Chemotherapy for Advanced Gastric Cancer With Peritoneal Metastatis

Inclusion Criteria: * Primary gastric adenocarcinoma diagnosed pathologically by endoscopic biopsy； * Laparoscopic exploration of patients with advanced gastric adenocarcinoma of peritoneal metastasis； * Eastern Cooperative Oncology Group (ECOG): 0 ot 1； * American Society of Anesthesiologists （ASA） score: I to Ⅲ； * Patient informed consent。 Exclusion Criteria: * Pregnancy or female in suckling period； * Severe mental illness； * Preoperative imaging or intraoperative exploration reveals distant blood, liver, lung, and brain metastases； * 5 years of history of other malignant diseases； * A history of unstable angina or myocardial infarction within 6 months； * History of cerebral infarction or cerebral hemorrhage within 6 months； * A history of sustained systemic corticosteroid treatment within 1 month； * Emergency operation due to complication (bleeding, perforation or obstruction) caused by primary tumor； * Pulmonary function test FEV1 \<predicted value 50%。