PeRioperative Omega Three and the Effect on ImmuNity (NCT03598413) | Clinical Trial Compass
CompletedNot Applicable
PeRioperative Omega Three and the Effect on ImmuNity
United Kingdom40 participantsStarted 2018-07-16
Plain-language summary
Bowel cancer is the second most common cause of cancer-related death in the UK, with 50,000 new cases and over 15,000 deaths annually. Surgery is the mainstay of treatment and the most common complications are an infection of the wound or lungs. These can lengthen hospital stay, reduce the quality of life, and even increase the risk of death. Bowel cancer patients are often malnourished. Optimising nutrition with supplements such as fish-oils can improve the immune response of patients, helping prevent such complications, shorten hospital stay, improve quality of life and overall survival.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with colorectal cancer undergoing elective laparoscopic colorectal resection.
* Adult aged 18 or over.
* Capacity to consent
Exclusion Criteria:
* Pre-existing diagnosis of Diabetes mellitus, requiring medication.
* Consumption of \> 3 alcoholic drinks/day
* Already on omega-3 supplementation
* Pregnant
* Patients on heparin infusion perioperatively
* Patients on immunosuppressive drugs
* Regular / Daily smokers
* Patients requiring a blood transfusion at any point day 7 pre-op to day 1 post operatively.
* Vegan or Vegetarian
* Allergy to cows milk or wheat
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Changes in Phagocytosis of pathogens
Timeframe: Baseline [2-4 weeks before surgery], Day of Surgery [day 7 post nutritional supplementation], Day 1 post surgery [day 8 post supplementation].
2
Changes in cell membrane composition
Timeframe: Baseline [2-4 weeks before surgery], Day of Surgery [day 7 post nutritional supplementation], Day 1 post surgery [day 8 post supplementation].
Trial details
NCT IDNCT03598413
SponsorRoyal Surrey County Hospital NHS Foundation Trust