Stopped: The study PI has left the institution.
The purpose of this study is to determine the extent to which severe burn injuries affect the morphology and function of liver, pancreas and thyroid. The evaluation of the liver will be performed non-invasively with liver fibrosis scores based on standard blood parameters and the measurement of liver stiffness (correlated with liver fibrosis) and controlled attenuation parameter (CAP, correlated with hepatic steatosis) via transient elastography (FibroScanĀ©, Echosens SA, Paris, France). The thyroid and the pancreas will be assessed via ultrasound (GE Medical Systems, Waukesha, USA) and standard blood parameters, respectively.
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Liver stiffness (kPa)
Timeframe: 24 months
Controlled Attenuation Parameter
Timeframe: 24 months
Liver diameter (cm)
Timeframe: 24 months
Platelet count (/nl)
Timeframe: 24 months
High-density lipoprotein (mg/dl)
Timeframe: 24 months
Low-density lipoprotein (mg/dl)
Timeframe: 24 months
Triglycerides (mg/dl)
Timeframe: 24 months
Cholesterol (mg/dl)
Timeframe: 24 months
Alanine-aminotransferase (U/dl)
Timeframe: 24 months
Aspartate-aminotransferase (U/dl)
Timeframe: 24 months
Gamma glutamyltransferase (U/dl)
Timeframe: 24 months
Alkaline phosphatase (U/dl)
Timeframe: 24 months
Bilirubin (ng/dl)
Timeframe: 24 months
Albumin (g/dl)
Timeframe: 24 months