Timed Aspirin Chronobiome Study

Inclusion criteria

• . Men and women greater than 18 years of age
• . Subjects must be in good health based on medical history, physical examination, vital signs, and laboratory tests. In order to ensure sufficient enrollment of subjects in the higher age groups, volunteers with the following conditions may participate in the study:
• . Adequately controlled hypertension, with diastolic blood pressure ≤100 mmHg at screening.
• . Total cholesterol of ≤270 mg/dL
• . Body mass index (BMI) between 18 and 30 kg/m2.
• . Has not used tobacco products, including smoking cessation nicotine-containing products (e.g., nicotine patch, nicotine gum), for at least the 3 months prior to screening.
• . Female subjects of child bearing potential must be using a medically acceptable method of contraception (oral contraception, Depo-Provera injection, IUD, condom with spermicide, diaphragm, cervical cap, progestin implant, abstinence, tubal ligation, oophorectomy, TAH) throughout the entire study period. All female subjects must consent to a serum and urine pregnancy test at screening and close-out and a urine pregnancy test just prior to the start of each treatment phase of the study, which must be negative at all time points.
• . All subjects must consent to a urine drug and nicotine test at screening. Results must be negative. A positive result will be reported to the subject.

Exclusion criteria