Fibrates in Pediatric Cholestasis

Inclusion Criteria: * Patient with chronic cholestatic liver disease defined as any condition in which substances normally excreted into bile are retained for more than 6 months. Exclusion Criteria: * Patients with anatomical or mechanical obstructive causes for cholestasis. * Cholestatic patients who were suffering from another liver disease. * Cholestatic patients who were receiving drugs affecting lipid profile. * Patients receiving drugs that interact with Fenofibrate (FF) e.g statins and warfarin * Patients with non obstructive gall bladder stones were excluded from T gp.