WithdrawnNot Applicable

Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis

Stopped: Change in study design

0Started 2030-01-01

Plain-language summary

This is a prospective, multicenter cohort observational; study to compare treatment outcomes in patients admitted to the hospital with Stevens-Johnsons Syndrome/Toxic Epidermolysis, aiming to assess the utility of medical management. The hypothesis of this study is that one or more treatment options will demonstrate improved patient outcomes. The primary objectives are cessation of progression of disease, time to complete re-epithelialization, length of stay, and mortality rate in the treatment groups as compared to those receiving supportive care alone. Exploratory analyses will assess the cause, risk factors, and severity prediction factors associated with the disease.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * a diagnosis of Stevens Johnsons Syndrome/Toxic Epidermal Necrolysis confirmed by examination of a dermatologist and/or skin biopsy plus described appropriate clinical findings (epidermal necrosis plus two involved mucosal surfaces) presenting within one week of disease onset Exclusion Criteria: * Pregnancy * Age \<18y * Decisional impairment * Incarceration * Onset of skin separation \>7d

What they're measuring

Mortality

Timeframe: 3 years

Time to cessation of new lesion formation

Timeframe: 3 years

Time to re-epithelialization

Timeframe: 3 years

Hospital length of stay

Timeframe: 3 years

Trial details

NCT IDNCT03585946

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2040-12-31

View on ClinicalTrials.gov More Stevens-Johnson Syndrome trials