The SHUNT-V Study for Varices

Inclusion Criteria: * Ability to have a peripheral venous catheter for administration of the 13C cholate * Ability to take the oral dose of d4-cholate * Ability to hold morning doses of medications for the 90-minute duration of the HepQuant SHUNT Test * Meets the protocol defined criteria for CLD in addition to having the diagnoses of CLD for \>6 months * Is scheduled, or in the process of being scheduled, for a standard of care EGD Exclusion Criteria: * Unable to give informed consent * Unable to obtain venous access for administration of intravenous cholate * Unable to absorb orally-administered cholate * Known hypersensitivity to human serum albumin * Known hypersensitivity to any of the components of the HepQuant SHUNT Liver Diagnostic Kit * Acute hepatitis or Acute Liver Failure * Acute drug-induced liver disease (DILI) * Noncirrhotic causes for portal hypertension and varices * Ongoing active alcoholic hepatitis * Child-Pugh class C defined by Child-Pugh score 10 or higher * Dialysis * Active infection or febrile illness within the last month * Documented history of esophageal or gastric variceal hemorrhage * Documented history of treatment of esophageal varices * Documented history of endoscopic findings of large esophageal varices * Hepatocellular carcinoma beyond Milan or University of California, San Francisco (UCSF) criteria * Thrombosis of main portal vein * Liver transplant recipient * Pregnancy * Women who are breast-feeding * Serious intercurrent medical or …