Active — Not RecruitingNot Applicable

DOTATOC PET/CT for Imaging NET Patients

Canada800 participantsStarted 2018-07-11

Plain-language summary

Neuroendocrine tumours (NETs) are generally slow growing, but some can be aggressive and resistant to treatment. Compared to healthy cells, the surface of these tumor cells has a greater number of special molecules called somatostatin receptors (SSTR). Somatostatin receptor scintigraphy and conventional imaging are used to detect NETs. This study proposes 68Gallium(68Ga)-DOTATOC positron emission tomography/computed tomography (PET/CT) is superior to current imaging techniques. The goal is to evaluate the safety and sensitivity of 68Ga-DOTATOC PET/CT at detecting NETs and other tumors with over-expression of somatostatin receptors.

Who can participate

Age range18 Years – 100 Years

SexALL

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Inclusion Criteria: All subjects: * World health organization performance status 0-2 * Able to provide written informed consent/assent (or consent by guardian for subjects \<19 years) * Patients must be able to tolerate the physical/logistical requirements of completing a PET scan including lying flat for up to 30 minutes and tolerating intravenous cannulation for injection. Patients must require imaging for either staging or re-staging of: * Gastroenteropancreatic tumors (e.g. carcinoids, gastrinoma, insulinoma, glucagonoma, VIPoma, etc.), functioning and non-functioning * Sympathoadrenal system tumors (phaeochromocytoma, paraganglioma, neuroblastoma, ganglioneuroma) * Medullary thyroid carcinoma * Pituitary adenoma * Medulloblastoma * Merkel cell carcinoma * Small-cell lung cancer (mainly primary tumors) * Meningioma * Or any other NET / with potential for overexpression of SSTR Exclusion Criteria: * Pregnancy * Patients who are medically unstable ex: acute cardiac or respiratory distress, hypotensive * Patients who exceed the safe weight limit of the PET/CT bed (204.5 kg) or who cannot fit through the PET/CT bore (diameter 70cm).

What they're measuring

Sensitivity of 68Ga-DOTATOC PET/CT in the diagnosis of SSTR positive tumors.

Timeframe: 3 years

Trial details

NCT IDNCT03583528

SponsorBritish Columbia Cancer Agency

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-09-30