Early Versus Delayed Double-guidewire Technique in Difficult Biliary Cannulation. (DFG)

Inclusion Criteria: * Patients 18 years old and more * Native papilla * Clinical indications of ERCP * Difficult biliary cannulation defined by unintentional guidewire insertion into the pancreatic duct before biliary cannulation is successful * Informed consent completed by the patient Exclusion Criteria: * Contraindication to upper gastrointestinal endoscopy * ERCP with direct biliary cannulation success * ERCP with inability to cannulate the bile duct nor the pancreatic duct * Coagulation or hemostasis disorder (TP \< 60%, TCA\> 40 sec. et plaquettes \< 60000/mm3). * Patient under active antiaggregant or anticoagulant medication other than aspirin * Endoscopic treatment of chronic pancreatitis * Pregnancy or breastfeeding * ERCP performed by another operator than an investigator * Patient's voluntary withdrawal * Withdrawal decision by the investigator or sponsor