CompletedNot Applicable

Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients

China1,206 participantsStarted 2017-11-28

Plain-language summary

The main purpose of this study is to compare the myocardial protection effect of intravenous metoprolol combined with remote ischemic conditioning (RIC) and single treatment before reperfusion in Chinese patients with anterior STEMI. This study sought to find possible strategies to further improve myocardial protection in Chinese patients with anterior STEMI.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. ages 18 to 80 years;
✓. presenting within 12 h of symptoms onset, with anterior STEMI and planned for pPCI; anterior STEMI was defined as the occurrence of \>20 min of chest pain and ST-segment elevation (\>2 mm) in at least 2 contiguous precordial leads;
✓. sign informed consent;

Exclusion criteria

✕. systolic blood pressure \< 110mmHg;
✕. cardiogenic shock or with heart failure symptoms, Killip III\~IV;
✕. allergic history of metoprolol;
✕. history of asthma or the need for bronchodilators;
✕. PR interval \> 240ms, II\~III atrioventricular block；
✕. heart rate \< 60 beats/min;
✕. unable to consent;
✕. pregnancy and lactation women;

What they're measuring

Myocardial infarct size

Timeframe: 60 hours

Trial details

NCT IDNCT03579914

SponsorHarbin Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-08-31

View on ClinicalTrials.gov More Anterior Myocardial Infarction trials