Continual surveillance of both community-acquired and nosocomial bloodstream infections for specific target organisms. Analysis of comorbidities, complications, bacterial resistance patterns, bacterial genomics (e. g. via WGS and MLST typing) for the determinants of clinical outcomes. The clinical outcomes are investigated both in the short-term (up until discharge) and the long-term (six months after index blood culture by standardized questionnaire). A predictive point-of-care score is to be developed based on these data to define high-risk patient populations requiring more intensive diagnostic and/or treatment regimens.
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Short-term mortality due to bloodstream infection
Timeframe: From index blood culture to discharge, an average of 16 days
Long-term mortality due to bloodstream infection
Timeframe: Up to 6 months
Long-term morbidity due to bloodstream infection
Timeframe: At 6 months
Evelina Tacconelli, Prof.