CompletedNot Applicable

Advanced Harmonic Generation Microscopy for Treatment Assessment of Cutaneous Pigmentary Disorder

Taiwan50 participantsStarted 2018-08-01

Plain-language summary

In this study, the investigators demonstrated that in vivo THG microscopy can differentiate Solar lentigos (SL), Nevus zygomaticus(NZ) and normal skin based on the optical nature of melanin. This THG-based procedure provides a valuable tool for noninvasive determination of third-order nonlinear susceptibility of melanin within the skin. It can also provide real-time histopathology information for treatment follow-up, without performing an invasive skin biopsy.

Who can participate

Age range20 Years – 85 Years

SexALL

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Inclusion criteria

✓. Subjects are aged 20 to 85 years at Screening, and can be either sex.
✓. Subjects are Fitzpatrick skin type III or IV.
✓. Subjects must have been diagnosed to have solar lentigos or nevus zygomaticus, which are larger than 4 mm in diameter on both sides of the face.

Exclusion criteria

✕. Subjects have previous treatments on the solar lentigos or nevus zygomaticus.
✕. Subjects have a history of adverse reaction to laser treatments, including allergy to topical anesthesia application.
✕. Subjects have a history of chronic inflammatory disorder such as atopic dermatitis on the face.
✕. Subjects are pregnant or breast feeding.
✕. Subjects have frequent sun exposure (≥4 hours per day).

What they're measuring

25 participants with Solar Lentigo and 25 participants with Nevus zygomaticus as assessed by clinical photographs

Timeframe: 6 months

Trial details

NCT IDNCT03578315

SponsorNational Taiwan University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-10-08

View on ClinicalTrials.gov More Solar Lentigo trials