This study determines if substituting full-fat yogurt (i.e., whole, 3.25% fat) for non-fat yogurt in the diet can reduce the risk of type 2 diabetes and inflammation in association with changes in the composition of the gastrointestinal bacteria prediabetic male and female volunteers. The central hypothesis is that dairy fat impacts whole body glucose handling and insulin sensitivity as well as inflammation both directly, and indirectly via influencing the gut microbiota composition.
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Changes in insulin sensitivity and β-cell function: MMTT
Timeframe: Baseline, 4 weeks, and 8 weeks
Changes in insulin sensitivity and β-cell function: OGTT
Timeframe: Baseline, 4 weeks, and 8 weeks