The purpose of this study is to test the efficacy of an oral, nutrient intervention containing the bioactive components of fish oil to promote healing of chronic venous leg ulcers (CVLUs) by reducing the chronic inflammation at wound sites that prevents healing progression. If this systemic, nutrient intervention is found to alter the microenvironment of CVLUs, the science of wound healing and care of patients with CVLUs will be vastly improved.
Age range
55 Years
Sex
ALL
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Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Intervention Effects on Plasma Levels of Lipid Mediator of Inflammation HEPE5
Timeframe: 0, 4, 8 and 12 weeks
Intervention Effects on Plasma Levels of Lipid Mediator of Inflammation HEPE11
Timeframe: 0, 4, 8 and 12 weeks
Intervention Effects on Plasma Levels of Lipid Mediator of Inflammation HEPE12
Timeframe: 0, 4, 8 and 12 weeks
Intervention Effects on Plasma Levels of Lipid Mediator of Inflammation HEPE15
Timeframe: 0, 4, 8 and 12 weeks
Intervention Effects on Plasma Levels of Lipid Mediator of Inflammation HEPE18
Timeframe: 0, 4, 8 and 12 weeks
Comparison of Intervention and Control Groups in IL-1β Levels (Log pg/mL)
Timeframe: 0, 4, 8 and 12 weeks
Comparison of Intervention and Control Groups in IL-6 Levels (Log pg/mL)
Timeframe: 0, 4, 8 and 12 weeks
1. Comparison of Intervention and Control Groups in TNF-α Levels (Log pg/mL)
Timeframe: 0, 4, 8 and 12 weeks
Comparison of Intervention and Control Groups in IFN-γ Levels (Log pg/mL)
Timeframe: 0, 4, 8 and 12 weeks
Intervention Effects on Polymorphonuclear Leukocyte (PMN) Activation (Log Cells/µL)
Timeframe: 0, 4, 8 and 12 weeks
Intervention Effects on Polymorphonuclear Leukocyte (PMN) - Derived Matrix Metalloproteinase-8 (MMP-8) Levels (Log pg/mg) in Wound Fluid
Timeframe: 0, 4, 8 and 12 weeks
Intervention Effects on Polymorphonuclear Leukocyte (PMN) - Derived Human Neutrophil Elastase (HNE, ELA2) Levels (Log pg/mg) in Wound Fluid
Timeframe: 0, 4, 8 and 12 weeks
Comparison of Intervention vs. Control Groups in the Percent Change in Wound Area Relative to Baseline
Timeframe: 0, 4, 8 and 12 weeks