IRELAnD: Investigating the Role of Early Low-dose Aspirin in Diabetes

Inclusion Criteria: * Singleton pregnancy with a pre-pregnancy diagnosis of type I or type II diabetes of at least 6 months' duration Exclusion Criteria: * • Aspirin hypersensitivity (prior bronchospasm/ urticarial/ angioedema with aspirin) * Peptic ulcer disease * Known bleeding diathesis * Multifetal gestation * Severe early-onset preeclampsia in a previous pregnancy * Patient already on aspirin * Established chronic renal disease/ macroalbuminuria * Chronic hypertension (antihypertensive therapy in first trimester) * Current selective serotonin reuptake inhibitor (SSRI) use (or SSRI use within 7 days) * Inability to speak or read English * Age less than 18 years * Use of any other investigational medicinal product within previous 30 days * Presence of any illness or condition that might interfere with the patient's ability to comply with the study procedures