WithdrawnNot Applicable

Individualized vs Low PEEP in One Lung Ventilation

Stopped: No subjects enrolled

United States0Started 2018-08-14

Plain-language summary

The aim of the prospective crossover study is to investigate the effect of individualized positive end-expiratory pressure (PEEP) on measures of tissue oxygenation, compared with low PEEP.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Subject undergoing elective pulmonary lobectomy requiring one-lung ventilation
✓. Body-mass index ≥ 30 kg/m2
✓. Age ≥ 18 years and ≤ 80 years

Exclusion criteria

✕. Age ≤ 18 year or ≥ 80 years
✕. Moderate or severe cardiac valvular disease
✕. Left ventricular ejection fraction \< 30%
✕. Moderate or severe right ventricular systolic dysfunction
✕. Severe pulmonary hypertension
✕. Presence of pulmonary bullae or blebs on preoperative chest imaging studies (e.g., radiograph, computed tomograph)
✕. Emergency surgery
✕. Previous history of lung surgery on the non-operative lung

What they're measuring

Cerebral oximetry

Timeframe: Change from baseline cerebral oximetry at the end of each intraoperative 20 minute experimental period. All measurements are made during the 4-6 hour surgery.

Trial details

NCT IDNCT03569774

SponsorDionne Peacher

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-05-19

View on ClinicalTrials.gov More One-Lung Ventilation trials