CompletedNot Applicable

Study of Arginine and Nitric Oxide in Patients With Diabetes

United States10 participantsStarted 2018-07-01

Plain-language summary

This study will test the effect of citrulline versus placebo supplementation in ketosis-prone diabetes (KPD) patients on arginine and nitric oxide production and on glucose- and arginine-stimulated insulin secretion and arterial flow-mediated dilation.

Who can participate

Age range20 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * New onset (defined as receiving a diagnosis within the past 1 year) diagnosis of unprovoked" A-β+ ketosis-prone diabetes * Aged 20-65 years * In good health except for diabetes without clinical evidence of micro- or macrovascular complications by history, physical exam and blood chemistries Exclusion Criteria: * Chronic or acute illness * History of myocardial infarction or coronary artery disease or stroke, * Renal insufficiency (eGFR \<90mL/min/1.73m2; \<30 mg albumin / g creatinine in urine) * Abnormal liver, thyroid, gonadal or adrenal functions * On medications other than metformin, * On any hormonal replacement therapy * Pregnancy

What they're measuring

Change in Arginine production

Timeframe: Three weeks

Trial details

NCT IDNCT03566524

SponsorBaylor College of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-06-30

View on ClinicalTrials.gov More Ketosis Prone Diabetes trials