To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning Objectives: To study the effect of administration of intravenous lipid emulsion on hemodynamic parameters, incidence of adverse effects in patients with organophosphate poisoning. Background: Lipid emulsion has been used to revert toxicities of lipophilic drugs, toxins (especially lignocaine) and in critically ill patients. Though the safety has been established, the effect on hemodynamics in Organophosphate (OP) poisoned patients has never been studied. Hence this study is underway to fill those lacunae and evaluate the safety profile of lipid emulsion in organophosphate poisoned patients. Methodology: The study is a prospective open label pilot study, which is underway at a tertiary care hospital in North India. Patients with history and clinical features of OP poisoning meeting the inclusion and exclusion parameters are being treated according to institutional protocols. Along with routine treatment a single dose of 20% lipid emulsion is being administered on admission to patients after obtaining consent. Patients are being followed up till discharge or death. Hemodynamic parameters and adverse effects following lipid emulsion administration are being studied over various intervals of time.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Significant change in pulse from baseline to 72 hours after admission
Timeframe: Date of admission up to 72 hours
Significant change in systolic blood pressure from baseline to 72 hours after admission
Timeframe: Date of admission up to 72 hours
Significant change in oxygen arterial saturation from baseline to 72 hours after admission
Timeframe: Date of admission up to 72 hours
Adverse effects
Timeframe: Date of admission until discharge/death of subjects up to 1 month
Significant change in diastolic blood pressure from baseline to 72 hours after admission
Timeframe: Date of admission up to 72 hours
Significant change in mean arterial pressure from baseline to 72 hours after admission
Timeframe: Date of admission up to 72 hours