CompletedNot Applicable

SAW Lung Microbiome Study in Smokers and Never-smokers

Germany60 participantsStarted 2017-03-29

Plain-language summary

The trial aims to analyse changes in the microbiome of the lower airways after smoking cessation. Microbiome analyses (upper airway swabs, bronchoalveolar lavage, transbronchial brushing) are conducted in smokers before and 6 weeks after smoking cessation. Never smokers serve as a control group and undergo the same sampling procedures once.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Cigarette consumption of at least five cigarettes per day * Caucasian ethnicity Exclusion Criteria: * Continous passive smoking exposure * Systemic steroid therapy during the previous month * Chronic lung disease (exception COPD stage Global Initiative on Lung Disease (GOLD) 0/I/II) * Diabetes mellitus * Pregnancy or breast feeding * active tuberculosis (currently or previously) * respiratory infection in the previous month * antibiotic therapy in the previous two months * immunosuppression * malignancy * interstitial lung disease * rheumatic disease with lung manifestation * member of a collaborative group of the project

What they're measuring

Change in microbiome pattern in smokers after smoking cessation

Timeframe: 6 Weeks

Trial details

NCT IDNCT03562442

SponsorResearch Center Borstel

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-12-31

View on ClinicalTrials.gov More Smoking Cessation trials