Spinal Cord Gray Matter Imaging in Post Polio Syndrome (NCT03561623) | Clinical Trial Compass
UnknownNot Applicable
Spinal Cord Gray Matter Imaging in Post Polio Syndrome
Switzerland40 participantsStarted 2017-05-22
Plain-language summary
This is a longitudinal, observational study with the aims of comparing spinal cord gray matter areas in patients with Post-Polio Syndrome to age and sex matched healthy control subjects and to correlate atrophy with metrics of clinical disability.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Prior paralytic poliomyelitis with evidence of motor neuron loss. This is confirmed by history of the acute paralytic illness, signs of residual weakness and atrophy of muscles on neuromuscular examination, and signs of motor neuron loss.
* a period of partial or complete functional recovery after acute paralytic poliomyelitis, followed by an interval (usually 15 years or more) of stable neuromuscular function.
* slowly progressive and persistent new muscle weakness or decreased endurance, with or without generalized fatigue, muscle atrophy, or muscle and joint pain. Symptoms that persist for at least a year.
* Exclusion of other neuromuscular, medical, and skeletal abnormalities as causes of symptoms.
* Patients older than 18 years at time of screening
* Ambulant
* Ability to walk 150 m in the 6 min walking distance (6MWT) with or without one or two walking sticks.
Exclusion Criteria:
* Previous (3 months or less) or concomitant participation in any other therapeutic trial
* known or suspected malignancy
* Other chronic disease or clinical relevant limitation of renal, liver, heart function according to discretion of investigator