Tetrahydrocannabinol (THC) and Sleep

Inclusion Criteria: * Frequent Cannabis Use (\>3x/week for the prior 3 months) or * No Cannabis Use (Less than 10x ever) Exclusion Criteria: * Sleep Apnea * Pregnancy * Diabetes * Cardiovascular disease * Chronic Pain * History of seizures * Severe Hepatic impairment * Conditions associated with clinically relevant cognitive impairment * Symptoms of acute or active illness (e.g., fever and leukocytosis) * Evidence of psychopathology on the Beck Depression Index II (BDI-II or in a structured clinical interview with a physician * History of severe psychiatric illnesses (including such as alcoholism, drug dependency including a cannabis use disorder score ≥12 on the Cannabis Use Disorders Identification Test (CUDIT) (28) or \>1 withdrawal symptom on the Marijuana Withdrawal Checklist (MWC (29)) , major depression, manic depressive illness, schizophrenic disorders, panic disorder, generalized anxiety disorder, post-traumatic stress disorder, agoraphobia, claustrophobia, paranoid personality disorder, schizoid personality disorder, schizotypal personality disorder, borderline personality disorder, and antisocial personality disorder.) * History of having been treated with antidepressants, neuroleptic medications, or tranquilizers. * Volunteers must be drug-free (including caffeine, nicotine, alcohol and herbal medications) for the duration of the screening and study period (with the exception of THC), with no dependence on drugs (e.g. cocaine, opioids, amphetamine, methamphetam…